CRI's clinical tools guides
Anti-TNFa therapy and safety monitoring
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A series of meetings between a group of experts and hospital or private rheumatologists devoted to the use of TNF-blocking drugs in the treatment of inflammatory rheumatism raised a large number of practical questions.

Under the aegis of the Club Rhumatismes et Inflammation (CRI, Inflammatory Rheumatisms Group of the French Society of Rheumatology, Société française de rhumatologie) and with the institutional support of Wyeth, we decided to provide answers as precise and as relevant as possible to these questions.

These answers are presented in the form of a clinical tool guide which propose management guidelines according to the diseases, symptoms and clinical situations to be managed during introduction or follow-up of anti-TNF therapy. These clinical practice sheets are completed by a pretreatment assessment checklist, and a standard information letter for the patient's attending physician.

We adopted the following methodology to elaborate these forms:

  • Identification of all of the questions raised,
  • Comprehensive review of the literature for each of these questions,
  • Elaboration of a reply weighted according to 3 levels of evidence (evidence-based medicine (EBM), official guidelines and expert opinions), presented in this document by three different colours.
  • Review of all of these clinical practice sheets by several experts of the CRI.

We hope that these clinical practice sheets, that can be downloaded from the CRI website and Science Direct (http://www.sciencedirect.com) will rapidly become a useful or even essential tool in your daily practice in order to promote the correct use of anti-TNF medications.

Avec l'aimable concours et l'autorisation
de la Revue du Rhumatisme et de sa version
en langue anglaise Joint Bone Spine

Xavier MARIETTE, Thao PHAM, Jean SIBILIA

The Clinical tool guide was written by:

Pr Pascal CLAUDEPIERRE, Dr Xavier DEPREZ, Pr Philippe GOUPILLE, Dr Pascal HILLIQUIN, DrThao PHAM, Dr Xavier PUÉCHAL, Pr Thierry SCHAEVERBEKE, Pr Jean SIBILIA, under Dr Thao PHAM and Pr Jean SIBILIA coordination.

It was reviewed by the CRI review committee:

Dr Bruno FAUTREL, Pr Xavier MARIETTE, Dr Charles MASSON, Dr Jacques MOREL, Pr Alain SARAUX, under Pr Xavier MARIETTE coordination.

Thao Pham1, Pascal Claudepierre2, Xavier Deprez3, Bruno Fautrel4, Philippe Goupille5, Pascal Hilliquin6, Charles Masson7, Jacques Morel8, Xavier Puéchal9, Alain Saraux10, Thierry Schaeverbeke11, Xavier Mariette12, Jean Sibilia13 for the CRI.

1 Service de Rhumatologie Sud, CHU-Hôpital de la Conception, 147 bd Baille, 13005 Marseille.
2 Service de Rhumatologie, CHU-Hôpital Henri Mondor, 51 avenue du Maréchal De Lattre de Tassigny, 94010 Créteil cedex 9.
3 Service de Rhumatologie, Pavillon Paul Fournier, CH de Valenciennes, 59322 Valenciennes cedex.
4 Service de Rhumatologie, CHU-Groupe Hospitalier Pitié-Salpétrière, 83 bd de l'Hôpital, 75651 Paris cedex 13.
5 Service de Rhumatologie, CHU-Hôpital Trousseau, Avenue de la République, 37044 Tours cedex 1.
6 Service de Rhumatologie, Hôpital Gilles de Corbeil, 59 bd Henri Dunant, 91106 Corbeil-Essonnes cedex.
7 Service de Rhumatologie, CHU Angers, 49033 Angers Cedex 1.
8 Fédération de Rhumatologie, CHU-Hôpital Lapeyronie, 371 avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 5.
9 Service de rhumatologie, CH du Mans, 194 avenue Rubillard, 72037 Le Mans cedex.
10 Service de Rhumatologie, CHU- Hôpital de la Cavale Blanche, rue Tanguy Prégent, 29609 Brest cedex.
11 Service de Rhumatologie, CHU-Hôpital Pellegrin, Place Amélie Raba Léon, 33076 Bordeaux cedex.
12 Service de Rhumatologie, CHU-Hôpital de Bicêtre, 78 ruedu Général Leclerc, 94270 Le Kremlin Bicêtre.
13 Service de Rhumatologie, CHU-Hôpital Hautepierre, 1 avenue Molière, 67098 Strasbourg cedex

© Elsevier SAS 2005
Joint Bone Spine Volume 72 supplément 1 page S1-S60 June 2005
publication originale en anglais

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